The Efficacy of Subcutaneous Versus Oral Methotrexate in Patients with Juvenile Idiopathic Arthritis
نویسندگان
چکیده
The aim of modern treatment of JIA is rapid induction of disease control to prevent joint damage, to maximize physical function and to achieve a normal lifestyle2. Medications that slow the progression of Rheumatoid arthritis are called disease modifying anti Rheumatic drugs (DMARDs). American College of Rheumatology (ACR) recommends early use of DMARDs, so that they can slow or help inhibition of joint damage.
منابع مشابه
Intolerance in oral versus subcutaneous administration of methotrexate in patients with juvenile idiopathic arthritis: a cross-sectional, observational study
Introduction Methotrexate (MTX) is the cornerstone disease-modifying anti-rheumatic drug in juvenile idiopathic arthritis (JIA), because of its efficacy. Moreover, serious adverse events are rare. However, in Dutch patients, MTX intolerance, defined as gastro-intestinal side effects occurring not only after, but also before administration of MTX and when thinking of the drug, occurred frequentl...
متن کاملPaediatric rheumatology Methotrexate bioavailability after oral and subcutaneous administration in children with juvenile idiopathic arthritis
Objective To compare the bioavailability of oral and subcutaneous methotrexate (MTX) in children with juvenile idiopathic
متن کاملMulticentric Carpotarsal Osteolysis Mimicking Juvenile Idiopathic Arthritis
Background Multicentric carpotarsal osteolysis (MCTO), a skeletal dysplasia presents in early childhood mimicking juvenile idiopathic arthritis (JIA). Recognition of this syndrome is essential to avoid unnecessary treatment with immunosuppressive agents because of different course and treatment. Case Report A 3-year-old boy presented with swelling and restriction of right wrist joint and left ...
متن کاملEfficacy of Subcutaneous Methotrexate in JIA Patients Who have Failed to Improve with Oral Methotrexate
Methotrexate is the most commonly used disease modifying anti-rheumatic drug (DMARDs) for rheumatoid arthritis1. However, some patients are intolerant to oral MTX despite folate supplementation and some patients do not respond adequately2. The route of administration of MTX in children with juvenile idiopathic arthritis (JIA) is not standardized and varies according to patient’s and treating ph...
متن کاملEfficacy of oral versus subcutaneous methotrexate in children with juvenile idiopathic arthritis
Methods According to MTX-administration route, children were divided into four groups: sc, po, switching from po to sc and from sc to po. Based on joint counts (pain, swelling and limited range of motion), patient's and physician's visual analogue scale for disease activity (VAS) and erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP), a combined overall disease activity score (ent...
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تاریخ انتشار 2010